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Metastatic pulmonary calcification
- Develops as a result of abnormalities in calcium and phosphate metabolism
- No correlation is, however, seen with the levels of serum calcium, phosphate, and parathormone or with the duration of hemodialysis
- Upper pulmonary lobes are more frequently involved, due to higher local blood pH and lower PaCO2, resulting in local alkaline environment
- The calcium complex deposited is stable, composed of calcium, magnesium and phosphate
and usually does not elicit an inflammatory reaction
- Some patients may develop restrictive lung disease and respiratory failure
- Calcifications can be found in pulmonary interstitium, pulmonary arterioles and bronchial walls
- Chest radiographs are often normal; when abnormal, they show consolidations and ill-defined nodules, which may mimic infection or pulmonary edema Computed tomography scan is a very sensitive imaging technique
- Although optimal treatment is not known, patients are usually treated with supplemental oxygen and phosphate binders 
- In severe cases of secondary hyperparathyroidism, parathyroidectomy is indicated.
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